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Suresh Mathews, Ph.D. |
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Assistant Professor
Poultry Science Building 101B
Auburn University
Auburn, AL 36849
Tel (334) 844-7418
Fax (334) 844-3268
mathest@auburn.edu
Division of Endocrinology, Wayne State Univ. School of Medicine, Detroit
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Lab Web-page: www.auburn.edu/~mathest
RESEARCH INTEREST
My research is focused on understanding the molecular mechanisms of insulin resistance, a hallmark of type 2 diabetes mellitus, which is characterized by an attenuated ability of peripheral target tissues to respond to insulin. A variety of hormones and metabolites such as leptin, adiponectin, resistin and TNF-ƒÑ are implicated in regulation of insulin sensitivity. My lab is specifically interested in characterizing the molecular mechanisms of a circulating protein called Alpha 2 Heremans Schmid Glycoprotein (AHSG, also known as fetuin, Gene symbol: AHSG or FETUA) that could potentially be a new physiological modulator of insulin action. AHSG is a phosphorylated glycoprotein, secreted by the liver into circulation that inhibits insulin receptor tyrosine kinase activity. Rats fed a high-fat diet demonstrate increased mRNA levels. Increased plasma protein levels are observed in patients with diabetes and which has been shown to correlate with insulin resistance. The human AHSG gene is mapped to chromosome 3q27; a region that is strongly linked to metabolic syndrome and recently identified as a type 2 diabetes-susceptibility locus. AHSG interacts with the activated insulin receptor. Recently, we have shown that Ahsg-null mice demonstrate improved insulin sensitivity and resistance to diet-induced obesity. Currently, our goal is to understand AHSG¡¦s mechanism of action, specifically the role of phosphorylation in insulin resistant conditions.
IN THE NEWS
Link to American Diabetes Association Researcher Database
Link to Community of Science Expertise Profile
Selected Publications
SELECTED PUBLICATIONS
Mathews ST, Selvam R: Effect of radical treatment on erythrocyte lipid peroxidation in Plasmodium vivax-infected malaria patients. Biochemistry International 25: 211-220, 1991
Mathews ST, Selvam R: Cholinesterase and acetylcholinesterase activities in patients infected with Plasmodium vivax. Medical Science Research 19: 807-809, 1991
Mathews ST, Kumaresan PR, Selvam R: Glucose-6-phosphate dehydrogenase deficiency and malaria-a study on North Madras population. Journal of Communicable Diseases 23: 178-181, 1991
Mathews ST, Selvam R: Peroxidative and antiperoxidative agents in red blood cells in human malaria In: Kidwai AM, Upreti RK, Ray PK (eds) Biomembranes in Health and Disease, Vol II. Today and Tomorrow's Printers and Publishers, New Delhi, pp.545-560, 1991
Selvam R, Mathews ST: Biochemical alterations in vivax malaria following radical treatment. Indian Journal of Malariology 29: 103-111, 1992
Mathews ST, Selvam R: Changes in glutathione metabolic enzymes in erythrocytes of Plasmodium vivax-infected patients. Clinica Chimica Acta 219: 159-165, 1993
Srinivas PR, Deutsch DD, Mathews ST, Goustin AS, Leon MA, Grunberger G: Recombinant human 2-HS glycoprotein inhibits insulin-stimulated mitogenic pathway without affecting metabolic signaling in Chinese Hamster Ovary cells overexpressing the human insulin receptor. Cellular Signaling 8: 567-573, 1996
Mathews ST, Srinivas PR, Leon MA, Grunberger G: Bovine fetuin is an inhibitor of insulin receptor tyrosine kinase. Life Sciences 61: 1583-1592, 1997
Mathews ST, Chellam N, Srinivas PR, Cintron VJ, Leon MA, Goustin AS, Grunberger G: 2-HSG, a specific and reversible inhibitor of insulin receptor autophosphorylation, interacts with the insulin receptor. Molecular and Cellular Endocrinology 164: 87-98, 2000
Grunberger G, Qiang X, Li Z-G, Mathews ST, Sbrissa D, Shisheva A, Sima AAF: Molecular basis for the insulinomimetic effects of C-peptide. Diabetologia 44:1247-1257, 2001
Mathews ST, Deutsch DD, Iyer G, Hora N, Pati B, Marsh J and Grunberger G. 2-HS glycoprotein kinetics after acute myocardial infarction: Development of a sandwich ELISA using commercial antibodies. Clinica Chimica Acta, 319:27-34, 2002
Grunberger G, Mathews ST, Deutsch DD: Tyrosine Kinase Inhibitors. In: Grunberger G, Zick Y (Eds): Insulin Signaling: From Cultured Cells to Animal Models, Frontiers in Animal Diabetes Research, Taylor & Francis Inc., pp.281-297, 2002
Mathews ST, Singh GP, Ranaletta M, Cintron VJ, Qiang X, Goustin AS, Jen K-LC, Charron MJ, Jahnen-Dechent W, Grunberger G: Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene. Diabetes 51:2450-2458, 2002
Chu AJ, Rauci M, Nwobi OI, Mathews ST, Beydoun S. Novel anticoagulant activity of polybrene: Inhibition of monocytic tissue factor hypercoagulation following bacterial endotoxin induction. Blood Coagulation and Fibrinolysis, 13: 123-128, 2002
Hegele RA, Cao H, Frankowski C, Mathews ST, Leff T: PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy. Diabetes 51:3586-3590, 2002
Chu AJ, Beydoun S, Mathews ST, Hoang J. Novel anticoagulant polyethylenimine suppresses blood coagulation: Inhibition of thrombin-catalyzed fibrin formation. Archives of Biochemistry and Biophysics 415:101-108, 2003
Chu AJ, Mathews ST. Anticoagulant potential of an antibody against factor VII. Journal of Surgical Research 114:37-41, 2003
Chu AJ, Rauci, M, Nwobi OI, Mathews ST, Beydoun S. Novel anticoagulant activity of polyamino acid offsets bacterial endotoxin-induced extrinsic hypercoagulation: Downregulation of monocytic tissue factor-dependent FVII activation. Journal of Cardiovascular Pharmacology 42:477-483, 2003
Chu, AJ, Mathews ST. Poly-L-hisditine downregulates fibrinolysis. Blood Coagulation and Fibrinolysis 14:627-632, 2003
Leff T, Mathews ST, Camp HS. PPAR, the adipocyte and diabetes. Experimental Diabesity Research 5:99-109, 2004
Mathews ST, Rakhade S, Zhou X, Coscina D, Grunberger G. Improved insulin sensitivity of fetuin-null mice protects aging-induced obesity and insulin resistance (American Journal of Physiology: Endocrinology and Metabolism, Communicated)
Current Course Information
NUFS 2000 – Nutrition and Health NUFS 7050 – Methods of Research
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